Surgery, Burn and Trauma Interventional Clinical Trials

A Multicenter, Randomized, Single-Blinded Study of Duration of Antibiotics for Intra- Abdominal Infection

• The major hypothesis to be tested is that the treatment of intraabdominal infections that have been adequately treated operatively or by percutaneous techniques with three to five days of antibiotics will result in outcomes equivalent to the current standard where treatment is carried out until the patient has returned to normal (normal white blood cell count, temperature, and intestinal function), of seven to 14 days of treatment.
• Subjects with an intraabdominal infection requiring any duration of hospitalization and managed with open, laparoscopic, or percutaneous intervention
• The primary investigator is Patrick J O'Neill, PhD, MD
• The study coordinator is Vanessa Bryan, CRC 602-360-0035

Prospective Evaluation of the Effects of Topical Therapy with Sulfamylon For 5% Topical Solution on Autograft Healing in Subjects with Thermal Injuries Requiring Meshed Autografts: A Comparison to a Historical Control Group.

• The objective of this study is to compare the effectiveness of treatment with Sulfamylon® solution as the initial topical moist dressing over meshed autografts following the initial graft procedure on preventing graft loss in a prospective cohort of subjects versus a historical control group in a non-inferiority trial
• Prospective subjects with thermal injuries of 20-60% TBSA on the chest, abdomen, or proximal upper and lower extremities requiring meshed autografts on these areas
• Patients will will receive SS5% as the initial topical moist dressing over the meshed autograft(s) placed at the initial graft procedure
• The primary investigator is Daniel Caruso, MD
• The study coordinator is Vanessa Bryan, CRC 602-360-0035

Clinical Study to Evaluate Effectiveness of Vashe Wound Therapy as a Post-Graft Irrigant in Burn Wound Management.

• This study will evaluate the efficacy, safety, and tolerability of topical Vashe™ Wound Therapy applied to gauze dressing every 6 hours or as necessary to keep dressing moist versus standard protocol with 5% Mafenide Acetate applied to gauze dressing every 6 hours or as necessary to keep dressing moist for a total treatment duration of 5 days.
• Prospective subjects with thermal injuries of 20% or less TBSA on the chest, abdomen, or proximal upper and lower extremities requiring wound excision and auto-grafting on these areas
• The primary investigator is Kevin Foster, MD
• The study coordinator is Karen Richey, BS, RN (602) 344-5152

Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients with Septic Shock

• The purpose of this placebo-controlled study is to determine if drotrecogin alfa (activated) treatment provides significant mortality reduction improvement in patients with septic shock compared with placebo treatment in patients receiving the current standard of care for septic shock.
• Subjects with septic shock as a result of infection and sepsis
• Adult Patients With Septic Shock will be randomized to receive Xigris or placebo administered as a continuous 96-hr infusion
• The primary investigator is Kevin Foster, MD
• The study coordinator is Starre Haney, RN

 

 

 

 

Last updated on June 9, 2010